{"id":11017,"date":"2026-04-17T19:21:55","date_gmt":"2026-04-17T19:21:55","guid":{"rendered":"https:\/\/wildgreenquest.com\/?p=11017"},"modified":"2026-04-17T19:21:55","modified_gmt":"2026-04-17T19:21:55","slug":"ai-needs-a-reality-check","status":"publish","type":"post","link":"https:\/\/wildgreenquest.com\/?p=11017","title":{"rendered":"AI needs a reality check"},"content":{"rendered":"<p><br \/>\n<br \/><\/p>\n<p>AI companies love to make bold claims about healthcare. Alphabet\u2019s <a rel=\"nofollow\" href=\"https:\/\/www.isomorphiclabs.com\/\">Isomorphic<\/a> tells us that \u201cfrontier AI can unlock deeper scientific insights, faster breakthroughs, and life-changing medicines.\u201d <a rel=\"nofollow\" href=\"https:\/\/www.lila.ai\/\">Lila<\/a> confidently markets its AI as a tool for &#8220;faster discovery for every field where breakthrough science matters.&#8221; And they\u2019re spending as though they believe the hype. Anthropic recently acquired stealth startup <a rel=\"nofollow\" href=\"https:\/\/www.fiercebiotech.com\/biotech\/anthropic-acquires-stealth-ai-startup-coefficient-bio-400m-deal\">Coefficient Bio<\/a> for $400 million.<\/p>\n<p>But there&#8217;s only one true test of any healthcare AI: Did it work in humans? Did it create a medicine that saved someone&#8217;s life?<\/p>\n<p>And bluntly, most companies have not achieved that. Let\u2019s look at the number of treatments brought to market. Isomorphic? None. Lila? The same. Marketing claims in AI rarely survive contact with reality.<\/p>\n<p>That&#8217;s because making real progress in healthcare is hard.<\/p>\n<p>To test a new treatment, you need to take it through a Phase 3 clinical trial. That&#8217;s typically 10 years and $2 billion. To test a diagnostic, you need to demonstrate clinical benefit, pass a rigorous third-party test, and build a full quality management system\u2014before your product is even permitted into the clinic. To uncover and prove new human biology? That could take decades of scientific experimentation.<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-close-the-gap\"><strong>CLOSE THE GAP<\/strong><\/h2>\n<p>So what do we need to do? The industry needs to close the gap between where AI models are trained and where medicine actually happens.<\/p>\n<p>That hard graft is what the best AI companies in the field are doing. Companies like Insilico Medicine and Recursion are advancing AI-discovered assets through clinical trials. At Owkin, we&#8217;ve taken OKN4395, our oncology drug, into the Phase 1a clinical INVOKE trial. Beyond that, we&#8217;ve trained our AI on real patient data for years and brought MSIntuit CRC through Europe\u2019s CE mark into pathology practice.<\/p>\n<p>This is hard work, but bringing your AI to patients has a big upside: It forces your AI to be better. From our experience, we&#8217;ve had to tackle unexpected, knotty problems. When we were first bringing diagnostic AI to the clinic, we realized that the models wouldn&#8217;t generalize well across population changes or scanner setups. We had to develop <a rel=\"nofollow\" href=\"https:\/\/www.owkin.com\/blogs-case-studies\/how-owkin-diagnostics-tackles-the-challenge-of-generalizability\">simple but robust methods<\/a> to adapt our models to the vagaries of individual locations and technologies.<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-improve-the-feedback-loop-in-real-time\"><strong>IMPROVE THE FEEDBACK LOOP IN REAL TIME<\/strong><\/h2>\n<p>We think that this \u201creality check\u201d\u2014testing our models\u2019 results with real patients\u2014is so important, that we\u2019ve built it into the structure of our INVOKE trial. In a traditional trial, the design looks only at the essential indicators of trial success and the interim results would decide whether the trial progresses. That\u2019s it. But unlike a traditional trial, we&#8217;re using ongoing data from our patient participants to improve our AI. Where our AI&#8217;s predictions about patients\u2019 responses have missed the mark, we have retrained it on the real data to improve its performance. It&#8217;s a positive feedback loop: The more information we get from real-life trials, the better our AI gets, the better it works for patients, the more models we can test.<\/p>\n<p>This is where the field is headed. There are different flavors. Some companies insert extra steps\u2014like testing their AIs&#8217; results on <em>in vitro<\/em> model systems (outside the body, like in Petri dishes)\u2014but eventually no drug-discovery, trial-design, diagnostic, or clinical AI can be successful without showing that the AI\u2019s results work in humans.<\/p>\n<p>But it doesn\u2019t all have to come from clinical trials.<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-model-training-data-can-be-varied\"><strong>MODEL TRAINING DATA CAN BE VARIED<\/strong><\/h2>\n<p>You can bring initial model predictions closer to reality by training those AI models on rich patient data. The more detailed the data descriptions, the broader the range of modalities, the more likely the signals the models pick up are real.<\/p>\n<p>When you need to test new AI-generated hypotheses and you can\u2019t do it with existing patient data, you can get as close to the patient as possible <em>in vitro<\/em>. For example, patient-derived organoids preserve human biological complexity that lab-grown cell lines and animal models lack, while also bringing a wealth of clinical information about the patient of origin.<\/p>\n<p>And you can test how models\u2019 predictions of patients\u2019 responses fare in the wild\u2014outside rigorously controlled testing settings\u2014with real human patients. <em>Quelel horreur!<\/em> That\u2019s the beauty of having a full stack ecosystem. When you make models that are used routinely in the clinic, like our diagnostic models, you get a real sense of their strengths, limitations, and where the real addressable clinical pain-points are.<\/p>\n<p>At Owkin, we do all of these things. It\u2019s not easy. It stretches us. And it forces us to confront the real barriers to bringing treatments to patients.<\/p>\n<p>This is the point in the article where I should be making my own visionary, outlandish claims\u2014something to really put my marketing team into panic mode. Something about how the future is going to change forever, about how close we are to some epoch-defining shift\u2026you know the kind of thing. But let me actually finish with something more grounded.<\/p>\n<p>It&#8217;s easy to get excited about the promise of AI. Believe me, I do. But it&#8217;s even more satisfying to watch all those dreams and expectations collide with reality, evaporate\u2014and see what survives. Because that is what\u2019s real.<\/p>\n<p><em>Thomas Clozel, MD, is cofounder and CEO of Owkin.<\/em><\/p>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.fastcompany.com\/91529003\/ai-needs-a-reality-check\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>AI companies love to make bold claims about healthcare. Alphabet\u2019s Isomorphic tells us that \u201cfrontier AI can unlock deeper scientific insights, faster breakthroughs, and life-changing medicines.\u201d Lila confidently markets its AI as a tool for &#8220;faster discovery for every field where breakthrough science matters.&#8221; And they\u2019re spending as though they believe the hype. Anthropic recently<\/p>\n","protected":false},"author":1,"featured_media":11018,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":{"0":"post-11017","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-brand-spotlights"},"_links":{"self":[{"href":"https:\/\/wildgreenquest.com\/index.php?rest_route=\/wp\/v2\/posts\/11017","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wildgreenquest.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wildgreenquest.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wildgreenquest.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wildgreenquest.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11017"}],"version-history":[{"count":0,"href":"https:\/\/wildgreenquest.com\/index.php?rest_route=\/wp\/v2\/posts\/11017\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wildgreenquest.com\/index.php?rest_route=\/wp\/v2\/media\/11018"}],"wp:attachment":[{"href":"https:\/\/wildgreenquest.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11017"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wildgreenquest.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11017"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wildgreenquest.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11017"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}